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作为听觉信息转换和传导的关键性传入结构，耳蜗带状突触有着特殊的分子表达，也是耳蜗衰老损伤的早发点。既往研究揭示了蛋白质稳态失衡是衰老改变的重要一环，其在耳蜗衰老中也有突出表现。我们回顾并讨论蛋白质稳态维持的两种主要降解机制，即泛素-蛋白酶系统（ubiquitin-proteasome system,UPS）及自噬-溶酶体途径（autophagy-lysosome pathway,ALP）。UPS和ALP是清除错误折叠或未折叠蛋白的关键机制，蛋白质降解机制失调的研究揭示了蛋白质稳态在耳蜗带状突触年龄损伤中的影响。蛋白质平衡的调控可能为年龄相关性听力损伤治疗提供多方面的潜在可能。
Abstract：The cochlear ribbon synapse is a crucial afferent structure for auditory information conversion and conduction, with special molecular expression. And this synapse has been described as an early-onset point in an aging cochlea. Previous studies have demonstrated that proteostasis is of great significance to aging changes, also true in cochlear aging. In this paper, we provide insights into the two major protein degradation pathways, i. e. the ubiquitin-proteasome system(UPS) and the autophagy-lysosome pathway(ALP), respectively, which are critical mechanisms for clearing misfolded or unfolded proteins. Studies on dysregulation of protein degradation mechanisms have revealed the influences of protein homeostasis on synaptic lesions in the aging cochlea. Therefore, regulating protein homeostasis may offer considerable and potential possibilities to treat age-related hearing loss.
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基本信息:
中图分类号:R764
引用信息:
[1]蔡玮,卢春键,谢慧.衰老耳蜗带状突触中的蛋白质稳态[J].中华耳科学杂志,2024,22(04):650-654.
基金信息:
四川省科技厅科技创新基地和人才计划项目（2022JDKP0018）
2024-08-15
2024-08-15