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耳鸣发病机制不明,外周听觉系统损伤可能是耳鸣的起因,但随着研究深入,中枢化机制逐渐成为近年来研究的热点。基于耳鸣动物模型开展的基础研究在耳鸣机制研究中占据重要地位。与耳鸣相关的脑区逐渐指向耳蜗核、下丘、听皮层等听觉通路上的重要区域,上述区域的病理变化可能是耳鸣形成和维持的原因;边缘系统作为与情绪相关的听觉外系统,可能参与耳鸣中枢调节的复杂过程。本文综述近年来涉及耳鸣相关脑区的基础研究进展,为探讨耳鸣中枢机制提供借鉴。
Abstract：The pathogenesis of tinnitus is unknown. Peripheral auditory system damage may be the cause of tinnitus, but with the proposal of neuroplasticity in tinnitus, the study of neuronal mechanism has become a hot spot in tinnitus research in recent years. Research based on animal model plays a very important role in tinnitus mechanism study.The brain regions associated with tinnitus point to important regions along auditory pathways such as the cochlear nucleus, inferior colliculus and auditory cortex. Pathological changes in these regions may be responsible for the formation and maintenance of tinnitus. The limbic system, as an emotion-related extra-auditory system, participates in the complicated process of tinnitus neuronal regulation. This review summarizes the progress in basic research of brain regions related to tinnitus in recent years and in attempt to provide a base for exploring the neuronal mechanism of tinnitus.
1 Eggermont J J.Tinnitus and Neural Plasticity(Tonndorf lecture at XI(th)International Tinnitus Seminar,Berlin,2014)[J].Hearing Research,2015,319:1-11.
2 Saunders J C.The Role of Central Nervous System Plasticity in Tinnitus.[J].Journal of Communication Disorders,2007,40(4):313.
3 Jastreboff P J,Brennan J F,Coleman J K,et al.Phantom Auditory Sensation in Rats:an Animal Model for Tinnitus[J].Behavioral Neuroscience,1988,102(102):811-822.
4 Brozoski TJ,Bauer CA.Animal Models of Tinnitus[J].Hearing Research,2016,338:88-97.
5 Turner J G,Brozoski T J,Bauer C A,et al.Gap Detection Deficits in Rats with Tinnitus:a Potential Novel Screening Tool[J].Behavioral Neuroscience,2006,120(1):188-195.
6 Luo H,Pace E,Zhang X,et al.Blast-Induced Tinnitus and Spontaneous Firing Changes in the Rat Dorsal Cochlear Nucleus[J].Journal of Neuroscience Research,2015,92(11):1466-1477.
7 Wu C,Martel D T,Shore S E.Increased Synchrony and Bursting of Dorsal Cochlear Nucleus Fusiform Cells Correlate with Tinnitus[J].Journal of Neuroscience the Official Journal of the Society for Neuroscience,2016,36(6):2068.
8 Luo H,Zhang X,Nation J,et al.Tinnitus Suppression by Electrical Stimulation of the Rat Dorsal Cochlear Nucleus[J].Neuroscience Letters,2012,522(1):16-20.
9 Wei L,Ding D,Sun W,et al.Effects of Sodium Salicylate on Spontaneous and Evoked Spike Rate in the Dorsal Cochlear Nucleus[J].Hearing Research,2010,267(1-2):54.
10 Stefanescu R A,Shore S E.NMDA Receptors Mediate Stimulus-Timing-Dependent Plasticity and Neural Synchrony in the Dorsal Cochlear Nucleus[J].Frontiers in Neural Circuits,2015,9:75.
11 Wu C,Stefanescu R A,Martel D T,et al.Tinnitus:Maladaptive Auditory-Somatosensory Plasticity[J].Hearing Research,2015,334:20-29.
12 Jeffrey B T,Wisner K W,Sybert L T,et al.Bilateral Dorsal Cochlear Nucleus Lesions Prevent Acoustic-Trauma Induced Tinnitus in an Animal Model[J].Journal of the Association for Research in Otolaryngology,2012,13(1):55.
13 Kraus K S,Ding D,Zhou Y,et al.Central Auditory Plasticity after Carboplatin-Induced Unilateral Inner Ear Damage in the Chinchilla:Up-Regulation of GAP-43 in the Ventral Cochlear Nucleus[J].Hearing Research,2009,255(1-2):33-43.
14 Coomber B,Kowalkowski V L,Berger J I,et al.Modulating Central Gain in Tinnitus:Changes in Nitric Oxide Synthase in the Ventral Cochlear Nucleus[J].Frontiers in Neurology,2014,6:53.
15 Fang L,Fu Y Y,Zhang T Y.Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear(MOC)Feedback Circui[J].Neurochemical Research,2016,41(6):1-11.
16 Berger J I,Coomber B.Tinnitus-Related Changes in the Inferior Colliculus[J].Frontiers in Neurology,2015,6:61.
17 Mulders W H,Robertson D.Development of Hyperactivity after Acoustic Trauma in the Guinea Pig Inferior Colliculus[J].Hearing Research,2013,298(1):104-108.
18 Wu J L,Chiu T W,Poon P W.Differential Changes in Fos-Immunoreactivity at the Auditory Brainstem after Chronic Injections o Salicylate in Rats[J].Hearing Research,2003,176(1-2):80.
19 Milbrandt J C,Holder T M,Wilson M C,et al.GAD Levels and Muscimol Binding in Rat Inferior Colliculus following Acoustic Trauma[J].Hearing Research,2000,147(1-2):251-260.
20刘俊秀,刘轶君,毛兰群,等.水杨酸钠对大鼠下丘多巴胺水平影响的研究[J].中华耳科学杂志,2016,14(2):167-169.Liu JX,Liu YJ,Mao LQ,et al.Effects of Salicylate on Dopamine Levels in Rat Inferior Colliculus[J].Chinese Journal of Otology2016,14(2):167-169.
21 Obara N,Kamiya H,Fukuda S.Serotonergic Modulation of Inhibitory Synaptic Transmission in Mouse Inferior Colliculus[J]Biomed Res,2014,35(1):81-84.
22 Butt S,Ashraf F,Porter L A,et al.Sodium Salicylate Reduces the Level of GABA B,Receptors in the Rat’s Inferior Colliculus[J]Neuroscience,2015,316:41-52.
23 Manzoor N F,Licari F G,Klapchar M,et al.Noise-Induced Hyperactivity in the Inferior Colliculus:Its Relationship with Hyperactivity in the Dorsal Cochlear Nucleus[J].Journal of Neurophysiology,2012,108(4):976-88.
24 Chen Y C,Li X,Liu L,et al.Tinnitus and Hyperacusis Involve Hyperactivity and Enhanced Connectivity in Auditory-Limbic-Arousal-Cerebellar Network[J].Elife Sciences,2015,4e06576.
25 Eggermont J J.Animal Models of Spontaneous Activity in the Healthy and Impaired Auditory System[J].Frontiers in Neural Circuits,2015,9(47):19.
26 Yang G,Lobarinas E,Zhang L,et al.Salicylate Induced Tinnitus:Behavioral Measures and Neural Activity in Auditory Cortex of Awake Rats[J].Hearing Research,2007,226(1-2):244-253.
27 Hu S S,Mei L,Chen J Y,et al.Expression of Immediate-Early Genes in the Inferior Colliculus and Auditory Cortex in Salicylate-Induced Tinnitus in Rat.[J].European Journal of Histochemistry Ejh,2014,58(1):2294.
28 Liu J,Xuepei L I,Liu Y,et al.Effects of Salicylate on Serotoninergic Activities in Rat Inferior Colliculus and Auditory Cortex[J].Hearing Research,2007,175(1-2):45.
29李明,黄喆慜,左传涛,等.视听觉屏蔽对特发性耳鸣患者脑内葡萄糖代谢分布的影响[J].中华耳鼻咽喉头颈外科杂志,2012,47(9):720-723.Li M,Huang ZM,Zuo CT,et al.Influence of Visual and Auditory Masking on the Brain Glucose Metabolism in an Idiopathic Tinnitus Patient[J].Chinese Journal of Otorhinolaryngology Head and Neck Surgery,2012,47(9):720-723.
30 Leaver A M,Seydell-Greenwald A,Rauschecker J P.Auditory-Limbic Interactions in Chronic Tinnitus:Challenges for Neuroimaging Research[J].Hearing Research,2016,334:49-57.
31 Zhang J,Luo H,Pace E,et al.Psychophysical and Neural Correlates of Noised-Induced Tinnitus in Animals:Intra-and Inter-Auditory and Non-Auditory Brain Structure Studies[J].Hearing Research,2016,334:7-19.
32 Yi B,Hu S,Zuo C,et al.Effects of Long-Term Salicylate Administration on Synaptic Ultrastructure and Metabolic Activity in the Rat CNS[J].Scientific Reports,2016,6:24428.
33刘行,廖华,杨琨,等.水杨酸钠致耳鸣大鼠模型海马区CRF1R的表达[J].临床耳鼻咽喉头颈外科杂志,2015(8):756-760.Liu X,Liao H,Yang K,et al.The Expression of Corticotropin-Releasing Factor 1 Receptor in Hippocampus of Rats Model of Salicylate Induced Tinnitus[J].Journal of Clinical Otorhinolaryngology Head and Neck Surgery,2015(8):756-760.
34刘俊秀,林雨青,毛兰群,等.水杨酸钠作用后大鼠海马内葡萄糖和乳酸水平变化[J].中国耳鼻咽喉头颈外科,2012,19(7):368-370.Liu JX,Lin YQ,Mao LQ,et al.Effects of Salicylate on the Glucose and Lactate Levels in Rat Hippocampus[J].Chinese Archives of Otolaryngology-Head and Neck Surgery,2012,19(7):368-370.
35赖仁淙,马鑫.听力损失与耳鸣的开关--阿控门[J].临床耳鼻咽喉头颈外科杂志,2017(7):493-495.Lai RC,Ma X.Hearing Loss and the Switch of Tinnitus-NAc[J].Journal of Clinical Otorhinolaryngology Head and Neck Surgery,2017(7):493-495.
36 Barry K M,Paolini A G,Robertson D,et al.Modulation of Medial Geniculate Nucleus Neuronal Activity by Electrical Stimulation of the Nucleus Accumbens[J].Neuroscience,2015,308:1-10.
基本信息:
中图分类号:R764.45
引用信息:
[1]兰家辉,李明,张剑宁.耳鸣中枢机制的基础研究进展[J].中华耳科学杂志,2018,16(01):102-106.
基金信息:
上海市申康发展中心新兴前沿技术联合攻关项目(No.SHDC12014125);; 上海市市属博士学科点建设基金(No.B201408)~~
2018-02-15
2018-02-15