滨州医学院特殊教育与康复学院听力与言语康复研究院;滨州医学院基础医学院;
老年性耳聋是听觉器官衰退引起的听觉障碍,对老年人的健康有严重影响。其发病机制主要与氧化应激、炎症、激素水平、遗传因素和环境因素等有关。目前改善听力的方法局限于使用听觉辅助装置,药物治疗、基因和干细胞治疗还在基础研究阶段,或能成为新的治疗选择。本文归纳了老年性耳聋的部分发病机制和治疗进展。
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[1] Bowl MR,Dawson SJ.Age-related hearing loss[J].Cold Spring Harb Perspect Med,2019,9(8):a033217.
[2]王静茹,韩佩佩,刘悦文,等.老年性聋听觉认知障碍的研究进展[J].中华耳科学杂志,2021,19(01):157-161.Wang JR,Han PP,Liu YW,et al.The relationship between age-related hearing loss and cognitive disorders:a review and recent developments[J].Chinese Journal of Otology,2021,19(01):157-161.
[3] Chern A,Golub JS.Age-related hearing loss and dementia[J].Alzheimer Dis Assoc Disord,2019,33(3):285-290.
[4] Del Mar Rivas-Chacon L,Yanes-Diaz J,de Lucas B,et al.Preventive effect of cocoa flavonoids via suppression of oxidative stress-induced apoptosis in auditory senescent cells[J].Antioxidants(Basel),2022,11(8):1450.
[5] Rousset F,Nacher-Soler G,Coelho M,et al.Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss[J].Redox Biol,2020,30:101434.
[6] Li J,Dai X,He X,et al.Effect of sod2 methylation on mitochondrial dna4834-bp deletion mutation in marginal cells under oxidative stress[J].Bosn J Basic Med Sci,2020,20(1):70-77.
[7] Oh J,Youn CK,Jun Y,et al.Reduced mitophagy in the cochlea of aged c57bl/6j mice[J].Exp Gerontol,2020,137:110946.
[8] Seicol BJ,Lin S,Xie R.Age-related hearing loss is accompanied by chronic inflammation in the cochlea and the cochlear nucleus[J].Front Aging Neurosci,2022,14:846804.
[9] Noble KV,Liu T,Matthews LJ,et al.Age-related changes in immune cells of the human cochlea[J].Front Neurol,2019,10:895.
[10] Lyu A-R,Kim TH,Park SJ,et al.Mitochondrial damage and necroptosis in aging cochlea[J].International Journal of Molecular Sciences,2020,21(7):2505.
[11] Sardone R,Lampignano L,Guerra V,et al.Relationship between inflammatory food consumption and age-related hearing loss in a prospective observational cohort:results from the salus in apulia study[J].Nutrients,2020,12(2):426.
[12] Beckman A,Conway GS,Cadge B.Audiological features of turner's syndrome in adults[J].Int J Audiol,2004,43(9):533-544.
[13] Kobrina A,Dent ML.The effects of age and sex on the detection of pure tones by adult cba/caj mice(mus musculus)[J].J Neurosci Res,2020,98(9):1731-1744.
[14] Feng ZY,Huang TL,Li XR,et al.17beta-estradiol promotes angiogenesis of stria vascular in cochlea of c57bl/6j mice[J].Eur J Pharmacol,2021,913:174642.
[15] Forouzanfar F,Asgharzade S.Micrornas in noise-induced hearing loss and their regulation by oxidative stress and inflammation[J].Curr Drug Targets,2020,21(12):1216-1224.
[16] Fetoni AR,Pisani A,Rolesi R,et al.Early noise-induced hearing loss accelerates presbycusis altering aging processes in the cochlea[J].Front Aging Neurosci,2022,14:803973.
[17] Moore BCJ,Lowe DA.Does exposure to noise during military service affect the progression of hearing loss with increasing age?[J].Trends Hear,2022,26:23312165221076940.
[18] Fuentes-Santamaria V,Alvarado JC,Mellado S,et al.Age-related inflammation and oxidative stress in the cochlea are exacerbated by long-term,short-duration noise stimulation[J].Front Aging Neurosci,2022,14:853320.
[19] Joo Y,Cruickshanks KJ,Klein BEK,et al.The contribution of ototoxic medications to hearing loss among older adults[J].J Gerontol A Biol Sci Med Sci,2020,75(3):561-566.
[20]赵宇亮,李熙星.顺铂耳毒性机制及耳保护策略研究进展[J].中华耳科学杂志,2021,19(01):167-171.Zhao YL,Li XX.Progress in research on protection strategies against and mechanisms of cisplatin ototoxicity[J].Chinese Journal of Otology,2021,19(01):167-171.
[21] Tang Q,Wang X,Jin H,et al.Cisplatin-induced ototoxicity:updates on molecular mechanisms and otoprotective strategies[J].Eur J Pharm Biopharm,2021,163:60-71.
[22] Benkafadar N,Francois F,Affortit C,et al.Ros-induced activation of dna damage responses drives senescence-like state in postmitotic cochlear cells:implication for hearing preservation[J].Mol Neurobiol,2019,56(8):5950-5969.
[23] Li Y,Zhao X,Hu Y,et al.Age-associated decline in nrf2 signaling and associated mtdna damage may be involved in the degeneration of the auditory cortex:implications for central presbycusis[J].Int J Mol Med,2018,42(6):3371-3385.
[24] Kim HJ,Cao W,Oh GS,et al.Augmentation of cellular nad(+)by nqo1 enzymatic action improves age-related hearing impairment[J].Aging Cell,2019,18(5):e13016.
[25] Polanski JF,Cruz OL.Evaluation of antioxidant treatment in presbyacusis:prospective,placebo-controlled,double-blind,randomised trial[J].The Journal of Laryngology&Otology,2013,127(2):134-141.
[26]吉琳,申琪,赵立东.老年性耳聋的治疗进展[J].中华耳科学杂志,2021,19(04):662-665.Ji L,Shen Q,Zhao LD.Progress in treatment of presbycusis[J].Chinese Journal of Otology,2021,19(04):662-665.
[27] Karah H,Karawani H.Auditory perceptual exercises in adults adapting to the use of hearing aids[J].Front Psychol,2022,13:832100.
[28] Garcia-Iza L,Martinez Z,Ugarte A,et al.Cochlear implantation in the elderly:outcomes,long-term evolution,and predictive factors[J].Eur Arch Otorhinolaryngol,2018,275(4):913-922.
[29] Ketterer MC,Knopke S,Haussler SM,et al.Asymmetric hearing loss and the benefit of cochlear implantation regarding speech perception,tinnitus burden and psychological comorbidities:a prospective follow-up study[J].Eur Arch Otorhinolaryngol,2018,275(11):2683-2693.
[30] Büchsenschütz K,Arnolds J,Bagus H,et al.Operatives risikoprofil und h?r-spracherfolg bei?lteren cochlea-implantat-patienten[J].Laryngo-Rhino-Otologie,2014,94(10):670-675.
[31] McCarty Walsh E,Morrison DR,McFeely WJ.Totally implantable active middle-ear implants:a large,single-surgeon cohort[J].J Laryngol Otol,2021,135(4):304-309.
[32] Cuda D,Murri A,Mainardi A,et al.Binaural hearing restoration with a bilateral fully implantable middle ear implant[J].Eur Arch Otorhinolaryngol,2021,278(7):2239-2246.
[33] Tao Y,Liu X,Yang L,et al.Aav-ie-k558r mediated cochlear gene therapy and hair cell regeneration[J].Signal Transduct Target Ther,2022,7(1):109.
[34] Wu J,Solanes P,Nist-Lund C,et al.Single and dual vector gene therapy with aav9-php.b rescues hearing in tmc1 mutant mice[J].Mol Ther,2021,29(3):973-988.
[35] Zhang J,Hou Z,Wang X,et al.Vegfa165 gene therapy ameliorates blood-labyrinth barrier breakdown and hearing loss[J].JCI Insight,2021,6(8):e143285.
[36]华荣恺,张志坚,华清泉.诱导性多能干细胞内耳移植的研究进展[J].中华耳科学杂志,2022,20(03):463-466.Hua RK,Zhang ZJ,Hua QQ.Advances in research on inner ear transplantation with induced pluripotent stem cells[J].Chinese Journal of Otology,2022,20(03):463-466.
[37] Dufner-Almeida LG,Cruz DBd,Mingroni Netto RC,et al.Stemcell therapy for hearing loss:are we there yet?[J].Brazilian Journal of Otorhinolaryngology,2019,85(4):520-529.
[38] Zhong C,Chen Z,Luo X,et al.Barhl1 is required for the differentiation of inner ear hair cell-like cells from mouse embryonic stem cells[J].Int J Biochem Cell Biol,2018,96:79-89.
[39] Ueda Y,Moore ST,Hashino E.Directed differentiation of human pluripotent stem cells into inner ear organoids[J].Methods Mol Biol,2022,2520:135-150.
[40] Eshraghi AA,Ocak E,Zhu A,et al.Biocompatibility of bone marrow-derived mesenchymal stem cells in the rat inner ear following trans-tympanic administration[J].J Clin Med,2020,9(6):1711.
基本信息:
DOI:
中图分类号:R764.436
引用信息:
[1]李木兰,王述立,郑庆印等.老年性耳聋发病机制及治疗进展[J].中华耳科学杂志,2025,23(01):124-127.
基金信息:
山东省自然科学基金重点项目(ZR2020KH025)